Dr. Erick Riquelme Sánchez

Investigación básica en enfermedades respiratorias del adulto

Cargo

Profesor Asistente

Contacto

emriquel@uc.cl

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Publicaciones:

  • Riquelme E, Carreño LJ, González PA, Kalergis AM. The duration of TCR/pMHC interactions regulates CTL effector function and tumor-killing capacity. Eur J Immunol 2009;39(8):2259-69.
  • Pacheco R, Riquelme E, Kalergis AM. Emerging evidence for the role of neurotransmitters in the modulation of T cell responses to cognate ligands. Cent Nerv Syst Agents Med Chem 2010;10(1):65-83.
  • Carreño LJ, Riquelme EM, González PA, Espagnolle N, Riedel CA, Valitutti S, Kalergis AM. T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC. Proc Natl Acad Sci USA 2010;107(1):210-5.
  • Yang F, Tang X, Riquelme E, Behrens C, Nilsson MB, Giri U, Varella-Garcia M, Byers LA, Lin HY, Wang J, Raso MG, Girard L, Coombes K, Lee JJ, Herbst RS, Minna JD, Heymach JV, and Wistuba II. Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy. Cancer Res 2011;71(16).
  • Behrens C, Luisa Solis L, Lin H, Yuan P, Tang X, Kadara H, Riquelme E, Galindo H, Moran C, Swisher S, Simon G, Stewart D, Lee J and Wistuba I.I. EZH2 protein expression associates to nonsmall cell lung carcinomas early pathogenesis, tumor progression and prognosis. Clin Cancer Res 2013;19(23):6556-65.
  • Riquelme E, Suraokar M, Behrens C, Lin H, Girard L, Lee J, Minna J, and Wistuba II. VEGF/VEGFR2 unregulated EZH2 expression and EZH2 depletion reduce malignant phenotype increasing the response to therapy platinum-based and against VEGFR-2 in lung adenocarcinoma. Clin Cancer Res 2014;20(14):3849-61.
  • Riquelme E, Suraokar M, Nunez M, Gazdar AF, Byers LA, John V. Heymach JV, Mehran RJ, Tsao A, Wistuba II. Copy Number Gain of MYC Locus is Frequently Observed in Malignant Pleural Mesothelioma. J Thorac Oncol 2014;9(7):998-1007.
  • Riquelme E, Shen L, Wang J, Behrens C, Minna JD, and Ignacio Wistuba II. Oncogenic KRAS Modulates EZH2 Expression Through MEK-ERK or PI3K/AKT Signaling in Lung Cancer Depending on the Subtype of KRAS Mutation. Cancer Res 2016;76(3):675-85.

  • Gopalakrishnan V, Spencer CN, Nezi L, Reuben A, Andrews MC, Karpinets TV, Prieto PA, Vicente D, Hoffman K, Wei SC, Cogdill AP, Zhao L, Hudgens CW, Hutchinson DS, Manzo T, Petaccia de Macedo M, Cotechini T, Kumar T, Chen WS, Reddy SM, Sloane RS, Galloway-Pena J, Jiang H, Chen PL, Shpall EJ, Rezvani K, Alousi AM, Chemaly RF, Shelburne S, Vence LM, Okhuysen PC, Jensen VB, Swennes AG, McAllister F, Riquelme-Sanchez EM, Zhang Y, Le Chatelier E, Zitvogel L, Pons N, AustinBreneman JL, Haydu LE, Burton EM, Gardner JM, Sirmans E, Hu J, Lazar AJ, Tsujikawa T, Diab A, Tawbi H, Glitza IC, Hwu WJ, Patel SP, Woodman SE, Amaria RN, Davies MA, Gershenwald JE, Hwu P, Lee JE, Zhang J, Coussens LM, Cooper ZA, Futreal PA, Daniel CR, Ajami NJ, Petrosino JF, Tetzlaff MT, Sharma P, Allison JP, Jenq RR, Wargo JA. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science. 2017 Nov 2.

  • Yu Zhang, Michelle Zoltan, Erick Riquelme, Ismet Sahin, Kyle Ch ang, Zhengyu Jiang, et al. Immunological regulation of stemness in pancreatic progenitor cells. Gastroenterology. 2018;155(1):210-23.
  • Chang K, Taggart MW, Reyes-Uribe L, Borras E, Riquelme E, Barnett RM, et al. Immune Profiling of Premalignant Lesions in Patients With Lynch Syndrome. JAMA Oncol 2018 Apr 16.
  • Riquelme E, Maitra A, McAllister F. Immunotherapy for Pancreatic Cancer: More Than Just a Gut Feeling. Cancer Discov. 2018;8(4):386-88.
  • Erick Riquelme, Yu Zhang, Liangliang Zhang, Montiel Maria, Zoltan Michelle, Wenli Dong, et al. Tumor Microbiome Diversity and Composition influence Pancreatic Cancer Outcomes. Cell 2019;178(4):795-806.
  • Yu Zhang, Vidhi Chandra, Erick Riquelme Sanchez, Prasanta Dutta, Pompeyo R. Quesada, Amanda Rakoski, et al. Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer. J Exp Med 2020;217(12).
  • Dutta P, Pando SC, Mascaro M, Riquelme E, Zoltan M, Zacharias NM, et al. Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy. Int J Mol Sci 2020;21(10):3722.
  • Riquelme E, McAllister F. Bacteria and fungi: The counteracting modulators of immune responses to radiation therapy in cancer. Cancer Cell. 2021 Sep 13;39(9):1173-1175.
  • Elgueta D, Murgas P, Riquelme E, Yang G, Cancino GI. Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring. Front Immunol 2022 Apr 7;13:816619.
  • Quesada PR, Riquelme E, Burks J, Rakoski A, Sahin I, McAllister F. Assessment of the Murine Tumor Microenvironment by Multiplex Immunofluorescence. Methods Mol Biol. 2022;2435:107-127.