Dr. Marcelo Andia K.

Departamento de Radiología y Centro de Imágenes Biomédicas UC

  • Subdirector Programas de Magíster y Doctorado.
  • Director Centro de Imágenes Biomédicas UC
  • Profesor Asociado Departamento de Radiología y Centro de Imágenes Biomédicas Pontificia Universidad Católica de Chile.
  • Ingeniero Civil de Industrias mención Mecánica, Pontificia Universidad Católica de Chile
  • Médico Cirujano, Pontificia Universidad Católica de Chile
  • Ph.D., Division of Imaging Sciences, School of Medicine, Kings College London, UK

Cargo

Subdirector Programas de Magísteres y Doctorados

Profesor Asociado

Director Centro de Imágenes Biomédicas UC

Teléfono

(+56)955048243

Contacto

meandia@uc.cl

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Formación Pregrado:

  • Ingeniero Civil de Industrias mención Mecánica, Pontificia Universidad Católica de Chile.
  • Médico Cirujano, Pontificia Universidad Católica de Chile.

 

Formación de Postgrado:

Ph.D., Division of Imaging Sciences, School of Medicine, Kings College London, UK.

Área de Investigación Doctorado Ciencias Médicas:

  • Enfermedades cardiovasculares y alteraciones de la hemostasia

Línea de Investigación:

  • Magnetic Resonance Imaging & Spectroscopy
  • Molecular Imaging
  • Cardiometabolic Magnetic Resonance.

Publicaciones relevantes:

  • Xavier A, Zacconi F, Santana-Romo F, Eykyn TR, Lavin B, Phinikaridou A, Botnar R, Uribe S, Oyarzún JE, Cabrera D, Arrese M, Andia ME. Assessment of hepatic fatty acids during non-alcoholic steatohepatitis progression using magnetic resonance spectroscopy. Ann Hepatol. 2021 Nov-Dec;25:100358. doi: 10.1016/j.aohep.2021.100358. Epub 2021 May 4. PMID: 33962045.

  • Aguirre-Reyes DF, Sotelo JA, Arab JP, Arrese M, Tejos R, Irarrazaval P, Tejos C, Uribe SA, Andia ME. Intrahepatic portal vein blood volume estimated by non-contrast magnetic resonance imaging for the assessment of portal hypertension. Magn Reson Imaging. 2015 Oct;33(8):970-7. doi: 10.1016/j.mri.2015.06.016. Epub 2015 Jun 25. PMID: 26117696.

  • Andia ME, Saha P, Jenkins J, Modarai B, Wiethoff AJ, Phinikaridou A, Grover SP, Patel AS, Schaeffter T, Smith A, Botnar RM. Fibrin-targeted magnetic resonance imaging allows in vivo quantification of thrombus fibrin content and identifies thrombi amenable for thrombolysis. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1193-1198. doi: 10.1161/ATVBAHA.113.302931. Epub 2014 Apr 10. PMID: 24723557; PMCID: PMC4195984.

Proyectos vigentes:

  • FONDECYT Regular 1220922, Improving metabolic phenotyping of MAFLD patients using Magnetic Resonance Spectroscopy and Machine Learning. Investigador responsable:   Marcelo Andía (Abril 2022-Marzo 2026).

  • Millennium Nucleus in Cardiovascular Magnetic Resonance, Director adjunto (2018-2022)
    Conoce más.

Actividades Docente-Asistenciales:

  • Director Magíster en Investigación en Ciencias de la Salud.
  • Director Centro de Imágenes Biomédicas UC

 

Investigaciones y proyectos:

  • Deputy Director, Millennium Nucleus in Cardiovascular Magnetic Resonance, CardioMR
  • Principal Investigator, Understanding the relationship between venous thrombosis and atherosclerosis: the monocyte link. Fondecyt Regular
  • Co-Investigator, Cardiovascular MR function: new insights from intracardiac flows and strain analysis. Fondecyt Regular 1181057
  • Co-Investigator, Studies on the contribution of endothelial dysfunction and platelet activation to the pathogenesis of thrombosis in inflammatory bowel disease. Fondecyt Regular 1171637
  • International Collaborator, Multi-sequence MRI characterization of deep vein thrombosis in man. British Heart Foundation, BHF15/89/31793
  • Co-Investigator, Free breathing 3D Cardiac Multiparametric MR Fingerprinting. Fondecyt Regular 1161055
  • Associate Researcher, Magnetic resonance imaging technology for aging related diseases: brain, heart and vessels. Anillo ACT1416
  • Co-Investigator, Non-invasive 3D full-field quantification of cardiovascular 4D flow MRI. Fondecyt 1141036
  • Principal Investigator, Development of contrast-free magnetic resonance angiography and tissue perfusion techniques. Fondecyt Regular 1130379
  • Principal Investigator, International network for research on cardiovascular magnetic resonance, King’s College London – Biomedical Imaging Centre UC. Redes120026
  • Associate Researcher, Biomedical imaging in obesity: from cellular mechanisms to clinical applications. Anillo ACT79
  • Co-Investigator, Evaluation of the stereotaxic radiosurgery effects using MRI. Pilot Grant in General Aspects of Magnetic Resonance in Medicine ISMRM

Publicaciones:

  1. Xavier A, Zacconi F, Santana-Romo F, Eykyn TR, Lavin B, Phinikaridou A, Botnar R, Uribe S, Oyarzún JE, Cabrera D, Arrese M, Andia ME. Assessment of hepatic fatty acids during non-alcoholic steatohepatitis progression using magnetic resonance spectroscopy. Ann Hepatol 2021; [Epub ahead of print].
  2. Rivera K, Quiñones V, Amigo L, Santander M, Salas-Pérez F, Xavier A, Fernández-Galilea M, Carrasco G, Cabrera D, Arrese M, Busso D, Andia ME, Rigotti A. Lipoprotein receptor SR-B1 deficiency enhances adipose tissue inflammation and reduces susceptibility to hepatic steatosis during diet-induced obesity in mice. Biochim Biophys Acta Mol Cell Biol Lipids 2021; 1866(6):158909
  3. Arrieta C, Sing-Long CA, Mura J, Irarrázaval P, Andia ME, Uribe S, Tejos C. Level set segmentation with shape prior knowledge using intrinsic rotation, translation and scaling alignment. Biomed Signal Process Control 2021;63;e102241
  4. Oyarzun JE, Andia ME, Uribe S, Nuñez-Pizarro P, Nuñez G, Montenegro G, Bridi R. Honeybee pollen extracts reduce oxidative stress and steatosis in hepatic cells. Molecules 2021; 26(1):e26010006
  5. Bridi R, von Poser GL, Gomez M, Andia ME, Oyarzún JE, Nuñez P, Vasquez-Arias AJ, Espinosa-Bustos C. Hepatoprotective species from the Chilean medicinal flora: Junellia spathulata (Verbenaceae). J Ethnopharmacol 2021; 267:113543
  6. Lavin B, Phinikaridou A, Andia ME, Potter M, Lorrio S, Rashid I, Botnar RM. Sustained focal vascular inflammation accelerates atherosclerosis in remote arteries. Arterioscler Thromb Vasc Biol 2020; 40(9):2159-2170.
  7. Xavier A, Arteaga de Castro C, Andia ME, Luijten PR, Klomp DW, Fillmer A, Prompers JJ. Metabolite cycled liver 1H MRS on a 7T parallel transmit system. NMR Biomed 2020; 33(8):e4343.
  8. Arrieta C, Urrutia J, Besa P, Montalba C, Lafont N, Andia ME, Uribe S. Automatic quantification of fat infiltration in paraspinal muscles using T2-weighted images: An Osirix application. Biomed Signal Process Control 2020; 57:e101793.
  9. Lavin B, Lacerda S; Andia ME, Lorrio S, Bakewell R, Smith A, Rashid I, Botnar RM, Phinikaridou A. Tropoelastin: An in vivo imaging marker of dysfunctional matrix turnover during abdominal aortic dilatation. Cardiovasc Res 2020;116(5):995-1005.
  10. Xavier A, Zacconi F, Gainza C, Cabrera D, Arrese M, Uribe S, Sing-Long C, Andia ME. Intrahepatic fatty acids composition as a biomarker of NAFLD progression from steatosis to NASH by using 1H-MRS. RSC Adv 2019; 9(72):42132-42139.
  11. Rivera K, Salas-Pérez F, Echeverría G, Urquiaga I, Dicenta S, Pérez D, de la Cerda P. González L, Andia ME, Uribe S, Tejos C, Martínez G, Busso D, Irarrázaval P, Rigotti A. Red wine grape pomace attenuates atherosclerosis and myocardial damage and increases survival in association with improved plasma antioxidant activity in a murine model of lethal ischemic heart disease. Nutrients 2019; 11(9):e002135.
  12. Ramos IT, Henningsson M, Nezafat M, Lavin B, Lorrio S, Gebhardt P, Protti A, Eykyn TR, Andia ME, Flögel U, Phinikaridou A, Shah AM, Botnar RM. Simultaneous assessment of cardiac inflammation and extracellular matrix remodelling after myocardial infarction. Circ Cardiovasc Imaging 2018; 11(11):e007453.
  13. Contreras-Duarte S, Chen P, Andia ME, Uribe S, Irarrazaval P, Kopp S, Kern S, Marsche G, Busso D, Wadsack C, Rigotti A. Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice. Biol Res 2018;15(1):34-44.
  14. Campos F, Abrigo J, Aguirre F, Garcés B, Arrese M, Karpen S, Cabrera D, Andia ME, Simon F, Cabello-Verrugio C. Sarcopenia in a mice model of chronic liver disease: Role of the ubiquitin-proteasome system and oxidative stress. Pflugers Arch – Eur J Physiol 2018; 470(10):1503-1519.
  15. Phinikaridou A, Lacerda S, Lavin B, Andia ME, Smith A, Saha P, Botnar RM. Tropoelastin: A novel marker for plaque progression and instability. Circ Cardiovasc Imaging 2018; 11(8):e007303.
  16. Urrutia J, Besa P, Lobos D, Andia ME, Arrieta C, Uribe S. Is a single level measurement of paraspinal muscle fat infiltration and cross-sectional area representative of the entire lumbar spine?. Skeletal Radiology 2018;47(7):939-945.
  17. Urrutia J, Besa P, Lobos D, Campos M, Arrieta C, Andia ME, Uribe S. Lumbar paraspinal muscle fat infiltration is independently associated with sex, age, and inter-vertebral disc degeneration in symptomatic patients. Skeletal Radiology 2018;47(7):955-961.
  18. Milovic C, Acosta-Cabronero J, Pinto JM, Mattern H, Andia ME, Uribe S, Tejos C. A new discrete dipole kernel for quantitative susceptibility mapping. Magn Reson Imaging 2018;51:7-13.
  19. Navarro ME, Razmilic D, Araos I, Rodrigo A, Andia ME. Contrast-enhanced spectral mammography: experience in 465 examinations. Rev Med Chile 2018;146(2):141-149.
  20. Montalba C, Urbina J, Sotelo J, Andia ME, Tejos C, Irarrázaval P, Valverde I, Uribe S. Variability of 4D flow parameters when subjected to changes in MRI acquisitions parameters using a realistic thoracic aortic phantom. Magn Reson Med 2018;79(4):1882-1892.
  21. Sotelo J, Urbina J, Valverde I, Mura J, Tejos C, Irarrazaval P, Andia ME, Hurtado D, Uribe S. Three-dimensional quantification of vorticity and helicity from 3D cine PC-MRI using finite-element interpolations. Magn Reson Med 2018;79(1):541-553.
  22. Sotelo J, Bächler P, Urbina J, Crelier G, Toro L, Ferreiro M, Valverde I, Andia ME, Tejos C, Irarrazaval P, Uribe S. Quantification of pulmonary regurgitation in patients with repaired Tetralogy of Fallot by 2D phase-contrast MRI: Differences between the standard method of velocity averaging and a pixel-wise analysis. JRSM Cardiovasc Dis 2017;6:e2048004017731986.
  23. Zamora T, Palma J, Andia ME, Garcia P, Wozniak A, Solar A, Campos M. Effect of Propionibacterium acnes (PA) injection on intervertebral disc degeneration in a rat model: does it mimic modic changes?. Orthop Traumatol Surg Res 2017;103(5):795-799.
  24. Videla A, Matamala LF, Uribe S, Andia ME. Ferrous ion oxidation monitoring by using magnetic resonance imaging for bio-oxidation laboratory testing. Miner Eng 2017;106:108-115.
  25. Arrieta C, Uribe S, Sing-Long C, Hurtado D, Andia ME, Irarrazaval P, Tejos C. Simultaneous left and right ventricle segmentation using topology preserving level sets. Biomed Signal Process Control 2017; 33:88-95.
  26. Phinikaridou A, Andia ME, Lavin-Plaza B, Smith A, Saha P, Botnar RM. Increased vascular permeability measured with an albumin-binding MR contrast agent is a surrogate marker of rupture-prone atherosclerotic plaque. Circ Cardiovasc Imaging 2016;9(12):e004910.
  27. Mura J, Pino AM, Sotelo J, Valverde I, Tejos C, Andia ME, Irarrazaval P, Uribe S. Enhancing the velocity data from 4D flow MR images by reducing its divergence. IEEE Trans Med Imaging 2016; 35(10):2353-2364.
  28. Arboleda C, Aguirre-Reyes D, Garcia MP, Tejos C, Muñoz L, Miquel JF, Irarrazaval P, Andia ME, Uribe S. Total liver fat quantification using three-dimensional respiratory self-navigated MRI sequence. Magn Reson Med 2016;76(5):1400-1409.
  29. Urbina J, Sotelo J, Springmüller D, Montalba C, Letelier K, Tejos C, Irarrázaval P, Andia ME, Razavi R, Valverde I, Uribe SA. Realistic aortic phantom to study hemodynamics using MRI and cardiac catheterization in normal and aortic coarctation conditions. J Magn Reson Imaging 2016; 44(3):683-697.
  30. Sotelo J, Urbina J, Valverde I, Tejos C, Irarrazaval P, Andia ME, Uribe S, Hurtado DE. 3D quantification of wall shear stress and oscillatory shear index using a finite-element method in 3D CINE PC-MRI data of the thoracic aorta. IEEE Trans Med Imaging 2016;35(6):1475-1487.
  31. Letelier K, Urbina J, Andia ME, Tejos C, Irarrazaval P, Prieto C, Uribe S. Accelerating dual cardiac phase images using undersampled radial phase encoding trajectories. Magn Reson Imaging 2016; 34(7):1017-1025.
  32. Aguirre-Reyes DF, Sotelo JA, Arab JP, Arrese M, Tejos R, Irarrazaval P, Tejos C, Uribe SA, Andia ME. Intrahepatic portal vein blood volume estimated by non-contrast Magnetic Resonance Imaging for the assessment of portal hypertension. Magn Reson Imaging 2015;33(8):970-7.
  33. Passacquale G, Phinikaridou A, Warboys C, Cooper M, Lavin B, Alfieri A, Andia ME, Botnar RM, Ferro A. Aspirin-induced histone acetylation in endothelial cells enhances synthesis of the secreted isoform of netrin-1 thus inhibiting monocyte vascular infiltration. Br J Pharmacol 2015;172(14):3548-64.
  34. Pinto JM, Arrieta C, Andia ME, Uribe S, Ramos-Grez J, Vargas A, Irarrazaval P, Tejos C. Sensitivity analysis of geometric errors in additive manufacturing medical models. Med Eng Phys 2015; 37(3):328-34.
  35. Hussain T, Henningsson M, Butzbach B, Lossnitzer D, Greil GF, Andia ME, Botnar RM. Combined coronary lumen and vessel wall MRI with i-T2prep: influence of nitroglycerin. Int J Cardiovasc Imaging 2015;31(1):77-82.
  36. Bigalke B, Phinikaridou A, Andia ME, Cooper MS, Schuster A, Wurster T, Onthank D, Münch G, Blower P, Gawaz M, Nagel E, Botnar RM. PET/CT and MR imaging biomarker of lipid-rich plaques using [64Cu]-labeled scavenger receptor (CD68-Fc). Int J Cardiol 2014;177(1):287-291.
  37. Miras AD, Seyfried F, Phinikaridou A, Andia ME, Christakis I, Spector AC, Botnar RM, Le Roux CW. Rats fed diets with different energy contribution from fat do not differ in adiposity. Obesity Facts 2014;7(5):302-310.
  38. Cadiz RF, Muñoz C, Tejos C, Andia ME, Uribe S, Irarrazaval P. Quantization error in magnetic resonance imaging. Concepts Magn Reson 2014;43A(3):79-89.
  39. Andia ME, Saha P, Jenkins J, Modarai B, Wiethoff AJ, Phinikaridou A, Grover SP, Patel AS, Schaeffter T, Smith A, Botnar RM. Fibrin targeted MRI allows in-vivo quantification of thrombus fibrin content and identifies thrombi amenable for thrombolysis. Arterioscler Thromb Vasc Biol 2014; 34(6):1193-1198.
  40. Phinikaridou A, Andia ME, Indermuehle A, Onthank DC, Cesati RR, Smith A, Robinson SP, Saha P, Botnar RM. Vascular remodelling and plaque vulnerability in a rabbit model of atherosclerosis: Comparison of delayed-enhancement MR imaging with an elastin-specific contrast agent and unenhanced black-blood MR imaging. Radiology 2014;271(2):390-399.
  41. Protti A, Dong X, Andia ME, Yu B, Dokukina K, Chaubey S, Phinikaridou A, Vizcay-Barrena G, Taupitz M, Botnar RM, Shah AM. Assessment of inflammation with a very small iron-oxide particle in a murine model of reperfused myocardial infarction. J Magn Reson Imaging 2014;39(3):598-608.
  42. Phinikaridou A, Andia ME, Lacerda S, Lorrio S, Makowski MR, Botnar RM. Molecular MRI of Atherosclerosis. Molecules 2013;18(11):14042-14069.
  43. Bigalke B, Phinikaridou A, Andia ME, Cooper MS, Schuster A, Schönberger T, Griessinger CM, Wuster T, Onthank D, Ungerer M, Gawaz M, Nagel E, Botnar RM. Positron Emission Tomography/Computed Tomographic and Magnetic Resonance Imaging in a Murine Model of Progressive Atherosclerosis Using 64Cu-Labeled Glycoprotein VI-Fc. Circ Cardiovasc Imaging 2013; 6(6):957-964.
  44. Andia ME*, Phinikaridou A*, Passacquale G, Ferro A, Botnar RM. Noninvasive MRI monitoring of the effect of interventions on endothelial permeability in murine atherosclerosis using an albumin-binding contrast agent. J Am Heart Assoc 2013; 2(5):e000402.
  45. Andia ME*, Saha P*, Modarai B, Blume U, Humphries J, Patel AS, Phinikaridou A, Evans CE, Mattock K, Grover S, Ahmad A, Lyons OT, Attia RQ, Renne T, Premaratne S, Wiethoff AJ, Botnar RM, Schaeffter T, Waltham M, Smith A. Magnetic resonance T1-relaxation time of venous thrombus is determined by iron processing and predicts susceptibility to lysis. Circulation 2013; 128(7):729-736.
  46. Milovic C, Oses C, Villalon M, Uribe S, Lizama C, Prieto C, Andia ME, Irarrazaval P, Tejos C. Calcium (Ca2+) waves data calibration and analysis using image processing techniques. BMC Bioinformatics 2013;14:162-175.
  47. Andia ME*, Phinikaridou A*, Saha P, Modarai B, Smith A, Botnar RM. In vivo magnetization transfer and diffusion weighted MRI detects thrombus composition in a mouse model of deep vein thrombosis. Circ Cardiovasc Imaging 2013;6:433-440.
  48. Meneses L, Fava M, Diaz P, Andia ME, Tejos C, Irarrazaval P, Uribe S. Embolization of incompetent pelvic veins is feasible as treatment for recurrent varicose veins in lower limbs and pelvic congestion syndrome. Cardiovasc Intervent Radiol 2013; 36(1):128-32.
  49. Andia ME, Henningsson M, Hussain T, Phinikaridou A, Protti A, Greil G, Botnar RM. Flow-independent 3D whole heart vessel wall imaging using an interleaved T2-preparation acquisition. Magn Reson Med 2013; 69(1):150-7.
  50. Phinikaridou A, Andia ME, Shah AM, Botnar R. Advances in Molecular Imaging of Atherosclerosis and Myocardial Infarction: Shedding New Light on In-vivo Cardiovascular Biology. Am J Physiol Heart Circ Physiol 2012; 303(12):1397-1410.
  51. Uribe S, Cadavid L, Hussain T, Parra R, Urcelay G, Heusser F, Andia ME, Tejos C, Irarrazaval P. Cardiovascular magnetic resonance findings in a pediatric population with isolated left ventricular non-compaction. J Cardiovasc Magn Reson 2012; 14(1):1-9.
  52. Prieto C, Andia ME, von Bary C, Schaeffter T, Botnar RM. Accelerating three-dimensional molecular cardiovascular MR imaging using compressed sensing. J Magn Reson Imaging 2012; 36(6):1362-71.
  53. Phinikaridou A, Andia ME, Protti A, Indermuehle A, Shah A, Smith A, Warley A, Botnar RM. Non-invasive MRI evaluation of endothelial permeability in murine atherosclerosis using an albumin-binding contrast agent. Circulation 2012; 126(6):707-719.
  54. Wurster T, Stellos K, Geisler T, Seizer P, Andia ME, Schuster A, May AE, Melms A, Gawaz M, Bigalke B. Expression of stromal-cell-derived factor-1 (SDF-1): a predictor of ischaemic stroke? Eur J Neurol 2012;19(3):395-401.
  55. Andia ME, Botnar RM. Arterial spin labeling angiography using a Triple Inversion Recovery prepulse. Magn Reson Med 2012; 67(2):477-83.

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