Dra. Sofia Waissbluth A.

Pérdida auditiva por quimioterapia - Otoneurología


Profesor Asistente Ordinario


(+56)22 354 3484




Médico-cirujano de la Universidad de Chile, especializada en otorrinolaringología en la UC. Además, obtuvo su título de doctorado en cirugía experimental, con especialización en pérdida auditiva por quimioterapia, en la Universidad de McGill, Canadá.

Formación de Pregrado:

  • Tecnología Médica, Dawson College, Canadá
  • Médico cirujano, Universidad de Chile

Formación de Postgrado:

  • Doctorado en cirugía experimental, Universidad de McGill, Canada
  • Otorrinolaringología, Pontificia Universidad Católica de Chile

Actividades docente-asistenciales:

Coordinadora y docente módulo de otoneurología, Sociedad Chilena de Otorrinolaringología.

Docente curso e internado de otorrinolaringología, Pontificia Universidad Católica de Chile.

Líneas de interés:

  • Otorrinolaringología general (adultos y niños)
  • Pérdida auditiva por quimioterapia

Artículos en revistas internacionales:

  1. COVIDSurg Collaborative. Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study. Anaesthesia. 2021 Jun;76(6):748-758.
  2. COVIDSurg Collaborative, GlobalSurg Collaborative. SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. Br J Surg. 2021 Mar 24:znab101.
  3. Waissbluth S, Sepulveda V. The Skull Vibration-Induced Nystagmus Test (SVINT) for Vestibular Disorders: A Systematic Review. Otol Neurotol. 2021 Jun 1;42(5):646-658.
  4. Waissbluth S. Is cyclosporine ototoxic? Front Neurol. 2020 Oct 22;11:593917
  5. Waissbluth S. Clinical trials evaluating transtympanic otoprotectants for CDDP-induced ototoxicity: what do we know so far? Eur Arch Otorhinolaryngol. Abril 2020.
  6. Pitaro J, Waissbluth S, Quintal MC, Abela A, Lapointe A. Characteristics of children with refractory acute otitis media treated at the pediatric emergency department. Int J Pediatr Otorhinolaryngol. 2019 Jan;116:173-176
  7. Waissbluth S, Del Valle Á, Chuang A, Becker A. Incidence and associated risk factors for platinum-induced ototoxicity in pediatric patients. Int J Pediatr Otorhinolaryngol. 2018;111:174-179
  8. Waissbluth S, Del Valle A, Chuang A, Cordova M. Long term platinum-induced ototoxicity in pediatric patients. Int J Ped Otol. Int J Pediatr Otorhinolaryngol. 2018;107:75-79
  9. Bhindi A, Waissbluth S, Al Qassabi B, Ywakim R, Manoukian J, Carpineta L, Nguyen 1. Hearing loss in pediatric temporal bone fractures; Evaluating two radiographic classification systems as prognosticators. Int J Pediatr Otorhinolaryngol. 2018;109:158-163
  10. Waissbluth S, Winter M, Dreyse X, Solar A, Castro J, Rosenblut A. Osteochondromyxoma of the nasal cavity: Case report and review of the literature. Eur J Med Case Rep 2018; 2(1)
  11. Waissbluth S. Garnier D, Akinpelu OV, Salehi P, Daniel SJ. The Impact of Erdosteine on Cisplatin-Induced Ototoxicity: A Proteomics Approach. Eur Arch Otorhinolaryngol. 2017;274:1365-1374.
  12. Waissbluth S, Peleva E, Daniel SJ. Platinum-Induced Ototoxicity: A Review of Prevailing Ototoxicity Criteria. Eur Arch Otorhinolaryngol. 2017;274:1187-1196
  13. Schwarz Y, Pitaro J, Waissbluth S, Daniel SJ. A clinical review of pediatric head and neck Pilomatrixoma. Int J Pediatr Otorhinolaryngol. 2016;85:148-53
  14. Waissbluth S, Ywakim R, Al Qassabi B, Torabi B, Carpineta L, Manoukian J, Nguyen 1. Pediatric temporal bone fractures: a case series. Int J Pediatr Otorhinolaryngol. 2016;84:106-9
  15. Salehi P, Akinpelu VO, Waissbluth S, Daniel SJ. Attenuation of Cisplatin ototoxicity by otoprotective effects of nanoencapsulated curcumin and dexamethasone in a Guinea pig model. Otol Neurotol 2014;35:1131-9
  16. Akinpelu VO, Ibrahim F, Waissbluth S, Daniel SJ. Histopathological changes in the cochlea as a consequence of diabetes mellitus – A review. Otol Neurotol 2014;35:764-74
  17. Akinpelu VO, Lemieux C, Citra D, Waissbluth S, Al-Marzouki H, Sahmkow S, Daniel SJ. EarigateTM for softening ear wax: Is it safe when the eardrum is perforated? Int J Ped Otorhinolaryngol. 2013;25:88-90
  18. Akinpelu VO, Waissbluth S, Daniel SJ. Auditory risk of hyperbilirubinemia in term newborns: a systematic review. Int J Pediatr Otorhinolaryngol. 2013;7:898-905
  19. Waissbluth S, Daniel SJ. Cisplatin-Induced Ototoxicity: Transporters Playing a Role in Cisplatin Influx. Hear Res. 2013;299:37-45
  20. Waissbluth S, Chan SW, Chen JZ, McIntosh M, Daniel SJ. RNA Preservation in Decalcified Cochlear Samples. Otol Neurotol. 2013;34:331-7
  21. Mujica-Mota M, Waissbluth S, Daniel SJ. Characteristics of Radiation-Induced Sensorineural Hearing Loss in Head and Neck Cancer: A Systematic Review. Head Neck. 2013;35:1662-8
  22. Waissbluth S, Salehi P, He X, Daniel SJ. Systemic dexamethasone for the prevention of cisplatin-induced ototoxicity. Eur Arch Otorhinolaryngol. 2013;270:1597-605
  23. Pitaro J, Waissbluth S, Daniel SJ. Do Children with Bell’s Palsy Benefit from Steroid Treatment? A Systematic Review. Int J Pediatr Otorhinolaryngol. 2012;76:921-6
  24. Waissbluth S, Pitaro J, Daniel SJ. Gene Therapy for Cisplatin-Induced Ototoxicity: A Systematic Review of In Vitro and Experimental Animal Studies. Otol Neurotol. 2012;33:302-10
  25. Waissbluth S, Dupuis I, Daniel SJ. Protective Effect of Erdosteine against Cisplatin-Induced Ototoxicity in a Guinea Pig Model. Otolaryngol Head Neck Surg. 2012;146:627-32

Artículos en revistas nacionales:

  1. Waissbluth S. Hearing loss: Screen, Rehabilitate, Communicate. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2021; 81:7-8
  2. Waissbluth S, Lira K, Aracena K, Oyarzun J, Willson M, Seiltgens C. Observed Frequency and Characteristics of Hearing Loss in Osteogenesis Imperfecta. Rev Med Chil. 2020 Dec;148(12):1781-1786.
  3. Garcia-Huidobro F, Rosenbaum A. Waissbluth S, Riveros H. Evaluation of transtympanic dexametasone in the management of refractory Ménière’s disease. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2021; 81: 181-191.
  4. Sepulveda V, Bravo-Grau S. Waissbluth S. Endolymphatic sac tumor: imaging case. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2021; 81: 243-245
  5. Álvarez ML, Waissbluth S, González C et al. How the COVID-19 pandemic affects specialty training: An analysis of a nationwide survey among otolaryngology residents in Chile. Medwave. 2021 Jan 8;21(1):e8098.
  6. Waissbluth S, García-Huidobro F, Araya-Céspedes M. The impact of COVID-19 preventive lockdowns on the prevalence of benign paroxysmal positional vertigo. Medwave. 2021 Apr 27;21(3):e8174
  7. Ramos P, Waissbluth S, Correa D, Aracena K. Benign paroxysmal positional vertigo: Associated risk factors and efficacy of particle repositioning maneuvers. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2020;80:19-27
  8. Holmberg J, Waissbluth S, Rosenblut A, Martoni M, Robles M, Palma S. Jehovah’s Witnesses patients in otorhinolaryngological surgery: A case regarding a sinonasal tumor resection. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2020;80:63-68
  9. Waissbluth S, Bravo S, Gutierrez C. Congenital internal auditory canal stenosis presenting with unilateral sensorineural hearing loss and facial nerve dysfunction. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2019;79:428-432
  10. Waissbluth S, Del Valle A, Toro C. Use of objective measures for cochlear implant programming. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2019;79:279-28
  11. Waissbluth S, Cabello P, Balcells ME, Solar A, Orellana MJ, San Martin J. Tuberculous otomastoiditis: A challenging diagnosis. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2019;79:173-178
  12. Waissbluth S, Muñoz T, Maul X, González C, Callejas C. The draf III procedure as an endoscopic frontal sinus approach. Red de Salud UC Christus’ experience. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2019;79:50-5
  13. Álvarez M, Santander MJ, Waissbluth S, Palma S. Clinical experience and management of peritonsillar abscesses at the dr. Sótero del Río Health Center. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2019;79:59-66
  14. Waissbluth S, Müller K, Cruz JP, Araya M, Ogrodnik R, González C. Isolated congenital anosmia: A case report. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2018;78:314-317
  15. Waissbluth S, García K, Imarai C. Endoscopic sinus surgery in the management of inverted papilloma: An analysis of 19 cases. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2018;78:127-13
  16. Lagos A, Waissbluth S, Heider C, Andrade T, Faba G. Rhinoseptoplasty: Three-year experience at the Pontificia Universidad Católica de Chile. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2018;78:245-25

Áreas de Investigación:

  • Ototoxicidad inducida por el cisplatino
  • Hipoacusia neurosensorial
  • Vestibulopatía bilateral
  • Vértigo


Miembro del comité editorial para la revista de la Sociedad Chilena de Otorrinolaringologia y Cirugía de Cabeza y Cuello

Revisora de artículos para varias revistas científicas internacionales