Investigación en Endocrinología
Cargo
Profesor Titular
Investigación Biomédica
Director del Instituto Milenio en Inmunología e Inmunoterapia
Áreas de investigación Doctorado Ciencias Médicas:
Líneas de Investigación:
Publicaciones relevantes:
Soto JA, Díaz FE, Retamal-Díaz A, Gálvez NMS, Melo-González F, Piña-Iturbe A, Ramírez MA, Bohmwald K, González PA, Bueno SM, Kalergis AM. BCG-Based Vaccines Elicit Antigen-Specific Adaptive and Trained Immunity against SARS-CoV-2 and Andes orthohantavirus. Vaccines (Basel). 2022 May 4;10(5):721. doi: 10.3390/vaccines10050721. PMID: 35632475; PMCID: PMC9143576.
Bohmwald K, Soto JA, Andrade-Parra C, Fernández-Fierro A, Espinoza JA, Ríos M, Eugenin EA, González PA, Opazo MC, Riedel CA, Kalergis AM. Lung pathology due to hRSV infection impairs blood-brain barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS. Brain Behav Immun. 2021 Jan;91:159-171. doi: 10.1016/j.bbi.2020.09.021. Epub 2020 Sep 24. PMID: 32979471; PMCID: PMC7513917.
Duarte LF, Gálvez NMS, Iturriaga C, Melo-González F, Soto JA, Schultz BM, Urzúa M, González LA, Vázquez Y, Ríos M, Berríos-Rojas RV, Rivera-Pérez D, Moreno-Tapia D, Pacheco GA, Vallejos OP, Hoppe-Elsholz G, Navarrete MS, Rojas Á, Fasce RA, Fernández J, Mora J, Ramírez E, Zeng G, Meng W, González-Aramundiz JV, González PA, Abarca K, Bueno SM, Kalergis AM. Immune Profile and Clinical Outcome of Breakthrough Cases After Vaccination With an Inactivated SARS-CoV-2 Vaccine. Front Immunol. 2021 Sep 29;12:742914. doi: 10.3389/fimmu.2021.742914. PMID: 34659237; PMCID: PMC8511644.
Proyectos vigentes:
ICN2021_045 Instituto Milenio en Inmunología e Inmunoterapia (IMII), Director: Alexis Kalergis. (Diciembre 2021-Diciembre 2031).
Conoce más.
FONDECYT Regular 1190830, Characterization of the clinical and immunological responses triggered by a BCG-based recombinant vaccine in healthy volunteers Investigador responsable: Alexis Kalergis (2019 – 2023).
BMRC Chile, Biomedical Research Consortium. Investigador responsible “Safe and Effective Vaccine against Human Metaoneumovirus (HMPV)” : Alexis Kalergis (2013-2023).
Conoce más.
PATH Sinovac Life Sciences Co. Ltda. Multicenter, phase 3, randomized clinical trial to evaluate the efficacy , safety and inmunigenicity of two vaccination schedules of an inactive vaccine against SARS-CoV-2 infection in adults, SINOVAC Estudio Clínico Ped CoronaVac03CL. Director General. Alexis Kalergis. (2021-2022).
Links de interés: