Dr. Arturo Borzutzky S.

Inmunología, Alergia y Reumatología Pediátrica

Laboratorio de Inmunología Traslacional

Cargo

Profesor Asociado

Jefe Sección Inmunología, Alergia y Reumatología Pediátrica

Jefe Laboratorio de Inmunología Traslacional UC

Teléfono

(+56)955043753

Contacto

arturobor@med.puc.cl

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Formación Pregrado:

Médico Cirujano. Escuela de Medicina, Pontificia Universidad Católica de Chile (1997-2003)

Formación Postgrado:

  • Especialización en Pediatría, Escuela de Medicina, Pontificia Universidad Católica de Chile (2004-2007)
  • Fellowship en Inmunología, Alergia y Reumatología Pediátrica, Boston Children’s Hospital, Harvard Medical School, Boston, Estados Unidos (2007-2010)

Área de Investigación Doctorado Ciencias Médicas:

  • Pediatría, Inmunología y Virología

Líneas de Investigación:

  • Dermatitis atópica
  • Alergia Alimentaria
  • Alergia e inmunología traslacional

Publicaciones relevantes:

  • Borzutzky A, Larco JI, Luna PC, McElwee E, Pires MC, Rico Restrepo M, Saez-de-Ocariz M, Sanchez J. Atopic Dermatitis in Latin America: A Roadmap to Address Data Collection, Knowledge Gaps, and Challenges. Dermatitis. 2022 Jun 1. doi: 10.1097/DER.0000000000000904. Epub ahead of print. PMID: 35648105.

  • Hernández CD, Casanello P, Harris PR, Castro-Rodríguez JA, Iturriaga C, Perez-Mateluna G, Farías M, Urzúa M, Hernandez C, Serrano C, Sandoval M, Hoyos-Bachiloglu R, Uauy R, Borzutzky A. Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile. BMC Pediatr. 2020 Apr 15;20(1):164. doi: 10.1186/s12887-020-02077-x. PMID: 32293348; PMCID: PMC7158062.

  • Hoyos-Bachiloglu R, Escobar JJ, Cifuentes C, Aguilera-Insunza R, Morales PS, Borzutzky A. Increasing food allergies in Chile, a developing country post-epidemiological transition. Pediatr Allergy Immunol. 2020 Jul;31(5):585-588. doi: 10.1111/pai.13225. Epub 2020 Feb 26. PMID: 32045033.

Proyectos vigentes:

  • FONDECYT Regular 1201568, Impact of vernix caseosa on the epidermal barrier and infection susceptibility: groundwork for a novel treatment against atopic dermatitis. Investigador responsable:   Arturo  Borzutzky (Abril 2020 – Marzo 2024).

Actividades Docentes Asistenciales:

Coordinador de Investigación Residentes de Pediatría

Miembro de Comité de Beca de Pediatría

Miembro de Comité de Investigación de Pediatría

Miembro del Claustro de Magíster de Nutrición UC

Clases Postgrado:

Curso Educación Continua para Residentes de Pediatría

Curso de Introducción a la Residencia en Pediatría

Clases lectivas para Residentes de Especialidades y Subespecialidades

Clases Pregrado:

Curso de Pediatría MED 504-A

Curso de Inmunología y Genética MED208A

Curso fisiopatología carreras nutrición, fonoaudiología, kinesiología MEN/MEK/MEF202A

Curso de fisiopatología pediátrica carrera de nutrición UC, MEN304.

Líneas de Investigación:

  • Dermatitis atópica
  • Alergia alimentaria
  • Efectos extraesqueléticos de la vitamina D
  • Enfermedad de Kawasaki
  • Enfermedades autoinflamatorias

Proyectos de Investigación:

“Identifying endotypes and potential therapeutic targets in atopic dermatitis through an integrated systems biology approach”. Principal Investigator: Arturo Borzutzky. FONDECYT Regular grant number 1160858, 2016-2020.

“Effects of Antarctic environment on vitamin D status and health risk biomarkers of its inhabitants.” Principal investigator. XXI Concurso Nacional de Proyectos de Investigación Científica y Tecnológica Antártica, Instituto Antártico Chileno. Project number RT_28-15. 2015-2018.

“Identification of non-invasive biomarkers of allergic proctocolitis.” Principal investigator. Concurso Regular de Investigación 2015. Sociedad Chilena de Pediatría. 2015-2017.

“A Multicenter, Open-Label Trial of Intravenous Golimumab, a Human Anti-TNFα Antibody, in Pediatric Subjects With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate Therapy (GO-VIVA) Protocol CNTO148JIA3003; Phase 3. Sponsor: Janssen Research & Development, LLC. Principal Investigator (Site Pontificia Universidad Católica de Chile). 2015-2022.

“Estudio prospectivo multicentrico, multinacional sobre la epidemiología, diagnóstico, tratamiento y publicaciones de la enfermedad de Kawasaki en niños de América Latina: REKAMLATINA-1.” Co-investigador. Sociedad Latinoamericana de Infectología Pediátrica (SLIPE) and the Kawasaki Disease Research Center & University of California, San Diego. Inicio año 2014.

 “Impact of vitamin D supplementation on clinical severity and immunologic tolerance of pediatric atopic dermatitis”. Principal Investigator. FONDECYT Regular Grant number 1130615, 2013-2016.

“Effect of H. pylori infection in the development of a tolerogenic immune response in children with IgE-mediated allergy”. Co-investigator. FONDECYT Regular Grant number 1130387, 2013-2016.

«Neurocognitive evaluation after severe infection by Respiratory Syncitial Virus in Infants». Principal Investigator. Proyecto Interdisciplina Grant number 14/2013, Vicerectoría de Investigación UC.

«A Randomized, Double-blind, Controlled Trial of Vitamin D for the Prevention of Acute Respiratory Infections in Children Aged 18 to 36 Months in Santiago, Coyhaique and Punta Arenas, Chile». Co-investigator. FONIS Grant Number SA13I20173. 2013-2017

«Vitamin D status, vitamin D receptor polymorphisms and tumoral expression in patients with sporadic and familial melanoma in Chilean population: a case control study.” PIs: Arturo Borzutzky, Monserrat Molgó, Sergio González. Proyecto Interdepartamental 05/14, Dirección de Investigación, Escuela de Medicina UC, 2014-2016.

«Clusters of autoimmune diseases in patients with pediatric autoimmunity», Senior investigator: Arturo Borzutzky, Resident Research Grant PG03/12, Dirección de Investigación, Facultad de Medicina UC.

«Prevalence of food allergy in Chilean school children», Principal Investigator Funding: Concurso 2011 División de Pediatría UC. 2011-2013.

«Epidemiology of immunologic and rheumatologic diseases in Chile.» Principal Investigator. Funding: División de Pediatría UC. 2011-2018.

«The PRES European Network of Registries for Autoinflammatory Diseases in Childhood (EuroFever).» Co-Investigator. Funding: Executive Agency for Health and Consumers (EAHC, Project No2007332) 2010-2018.

ANID, PIA, Anillo CyT, ACT172097, Early origins of allergy and asthma (ARIES). 2018-2021

Publicaciones:

Publicaciones ISI más recientes

  1. Hernández-Ojeda A, Rojas N, Barriga F, Wietstruck MA, Morales PS, Borzutzky A. Incidence and risk factors of food allergy after umbilical cord blood transplantation in children. J Allergy Clin Immunol Pract. 2017; pii: S2213-2198(17)30350-1. doi: 10.1016/j.jaip.2017.04.034.
  2. Starokadomskyy P, Sifuentes-Dominguez L, Gemelli T, Zinn AR,Dossi MT, Mellado C, Bertrand P, Borzutzky A, Burstein E. Evolution of the skin manifestations of X-linked Pigmentary Reticulate Disorder. Brit J Dermatol. 2017; in press.
  3. Navarrete-Dechent C, Del Puerto C, Molgo M, González S, Perez-Mateluna G, Uribe P, Camargo CA, Borzutzky A. Circulating vitamin D-binding protein and free 25-hydroxyvitamin D concentrations in patients with melanoma: a case-control study. J Am Acad Dermatol. 2017; in press.
  4. Jaime F, Riutort MC, Alvarez-Lobos M, Hoyos-Bachiloglu R, Camargo CA, Borzutzky A. Solar radiation is inversely associated with inflammatory bowel disease admissions. Scand J Gastroenterol. 2017; 52(6-7):730-737.
  5. Balcells ME, Cerda J, Concha S, Hoyos-Bachiloglu R, Camargo CA, Martineau AR, Borzutzky A. Regional solar radiation is inversely correlated with incidence and severity of tuberculosis in Chile. Epidemiol Infect. 2017; 3:1-9. doi: 10.1017/S0950268817000607.
  6. Poli C, Hoyos-Bachiloglu R, Borzutzky A. Primary immunodeficiencies in Chile evaluated through ICD-10 coded hospital admissions. Allergol Immunopathol (Madr). 2017; 45:33-39. doi: 10.1016/j.aller.2016.05.004.
  7. Flores JC, Bohmwald K, Espinoza J, Jara C, Peña M, Hoyos-Bachiloglu R, Iturriaga C, Kalergis AM, Borzutzky A. Potential neurocognitive consequences of infection by human Respiratory Syncytial Virus. Rev Chilena Infectol. 2016; 33:537-542.
  8. Del Puerto C, Navarrete-Dechent C, Molgo M, Borzutzky A, Gonzalez S. Vitamin D axis and its role in skin carcinogenesis: a comprehensive review. Applied Cancer Research. 2016; 36:5. DOI: 10.1186/s41241-016-0006-4.
  9. Ontiveros N, Valdez-Meza EE, Vergara-Jiménez MJ, Canizalez-Román A, Borzutzky A, Cabrera-Chávez F. Parent-Reported Prevalence of Food Allergy in Mexican Schoolchildren: A Population-Based Study. Allergol Immunopathol (Madr). 2016; 44(6): 563-570. doi: 10.1016/j.aller.2016.03.003.
  10. Navarrete-Dechent C, Perez-Mateluna G, Silva-Valenzuela S, Vera-Kellet C, Borzutzky A. Humoral and cellular autoreactivity to epidermal proteins in atopic dermatitis. Arch Immunol Ther Exp (Warsz). 2016; 64:435-442. doi: 10.1007/s00005-016-0400-3.
  11. Hoyos-Bachiloglu R, García A, Morales PS, Cerda J, Talesnik E, Borzutzky A. Geographic distribution of Kawasaki disease in Chile. Rev Chilena Infectol. 2016; 33:12-18.
  12. Torres A, Newton SA, Crompton B, Borzutzky A, Neufeld EJ, Notarangelo L, Berry GT. CSF 5-Methyltetrahydrofolate Serial Monitoring to Guide Treatment of Congenital Folate Malabsorption Due to Proton-Coupled Folate Transporter (PCFT) Deficiency. JIMD Rep. 2015;24:91-6. doi: 10.1007/8904_2015_445.
  13. Brinkmann K, Le Roy C, Iñiguez G, Borzutzky A. Severe vitamin D deficiency in children from Punta Arenas, Chile: influence of nutritional status and response to supplementation. Rev Chil Pediatr. 2015; 86:182-88.
  14. Jorquera H, Borzutzky A, Hoyos-Bachiloglu R, García A. Association of Kawasaki Disease with Tropospheric Winds in Central Chile: Is Wind-Borne Desert Dust a Risk Factor? Environ Int. 2015;78C: 32-38. doi: 10.1016/j.envint.2015.02.007.
  15. Fuentes R, Sandoval D, Borzutzky A, Nazar C. Alergia al latex en el período perioperatorio. Rev Chil Cirugía 2015; 67: 318-324.
  16. Aird A, Aranguiz P, Barria R, Borzutzky A, De la Puente L, Diaz MM, et al. Guía Clínica GES de Artritis Idiopática Juvenil 2014. Rev. Chil. Reumatol. 2014; 30(3): 98-118.
  17. Borzutzky A, Hoyos-Bachiloglu R, Navarrete-Dechent C, Vera-Kellet C, Silva-Valenzuela S, Cifuentes L, Iturriaga C, Cristi F. Agreement Between Dermatologic and Pediatric Researchers in Scoring of Atopic Dermatitis in Children. Pediatr Dermatol. 2014;31(6):e118-9.
  18. Borzutzky A, Morales PS, Mezzano V, Nussbaum S, Burks AW. Induction of Remission of Idiopathic Anaphylaxis with Rituximab. J Allergy Clin Immunol. 2014:134(4):981-3.
  19. Hoyos-Bachiloglu R, Morales PS, Cerda J, Talesnik E, González G, Camargo CA, Borzutzky A. Higher latitude and lower solar radiation influence on anaphylaxis in Chilean children. Pediatr Allergy Immunol. 2014; 25(4): 338-43.
  20. Kumar L, Chou J, Yee C, Borzutzky A, Vollmann E, von Andrian U, Park SY, Hollander G, Manis J, Poliani P, Geha RS. Leucine Rich Repeat Containing 8A (LRRC8A) is Essential for T Lymphocyte Development and Function. J Exp Med. 2014; 211(5):929-42.
  21. Hoyos Bachiloglu R, Ivanovic-Zuvic D, Alvarez J, Linn K, Thone N, Paul MA, Borzutzky A. Prevalence of parent-reported immediate hypersensitivity food allergy in Chilean school-aged children. Allergol Immunopathol (Madr). 2014;42(6): 527-32.
  22. Borzutzky A, Grob F, Camargo CA, Martínez-Aguayo A. Vitamin D deficiency rickets in an adolescent with severe atopic dermatitis. Pediatrics 2014; 133(2):e451-4.
  23. Borzutzky A, Camargo CA. Role of vitamin D in the pathogenesis and treatment of atopic dermatitis. Exp Rev Clin Immunol 2013; 9(8): 751-760.
  24. Ter Haar N, Lachmann H, Özen S, Woo P, Uziel Y, Modesto C, et al; Paediatric Rheumatology International Trials Organisation (PRINTO) and the Eurofever/Eurotraps Projects. Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review. Ann Rheum Dis. 2013; 72(5):678-85.
  25. Borzutzky A, Stern S, Reiff A, Zurakowski D, Steinberg EA, Dedeoglu F, Sundel RP. Pediatric chronic nonbacterial osteomyelitis. Pediatrics 2012;130: e1190-7.
  26. Jabara HH, McDonald DR, Janssen E, Massaad MJ, Ramesh N, Borzutzky A, Rauter I, et al. DOCK8 functions as an adaptor that links TLR/MyD88 signaling to B cell activation. Nat Immunol. 2012; 13(6):612-20.
  27. Morales PS, Escobar RG, Lizama M, Aglony M, Salomon J, Drenth JPH, Borzutzky A. Pediatric hypertension-associated erythromelalgia responds to corticosteroids and is not associated to SCN9A mutations. 2012; 51(12):2295-6.
  28. Nuñez-Farías AC, Borzutzky A, Morales PS, Zunino R, Del Villar S. Reply: To PMID 23140611. J Pediatr. 2013; 162(1):217.
  29. Nuñez-Farías AC, Borzutzky A, Morales PS, Zunino R, Del Villar S. Severe spinal neurofibromatosis in a child. J Pediatr. 2012; 161(2):368-368.e1.
  30. Vergara C, Borzutzky A, Gutierrez MA, Iacobelli S, Talesnik E, Martinez ME, Stange L, Basualdo J, Maluje V, Jimenez R, Wiener R, Tinoco J, Jarpa E, Aróstegui JI, Yagüe J, Alvarez-Lobos M. Clinical and genetic features of hereditary periodic fever syndromes in Hispanic patients: the Chilean experience. Clin Rheumatol. 2012; 31(5):829-34.
  31. Borzutzky A, Hoyos-Bachiloglu R, Cerda J, Talesnik E. Rising hospitalization rates of Kawasaki disease in Chile between 2001 and 2007. Rheumatol Int. 2012; 32:2491-95.

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