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  2. Dr. Cristián Carvajal M.

Dr. Cristián Carvajal M.

Investigación Biomedica en Endocrinología
Dr. Cristián Carvajal M.
Cargo

Profesor Asociado

Director Ciencias Básicas, Centro Traslacional de Endocrinologia UC

Contacto
email ccarvajm@uc.cl phone 2 23543095 (Oficina académica) phone 2 23543634 (Laboratorio) phone 2 23543639

Resumen

El Dr Cristian A. Carvajal es magister en Bioquímica y Doctor en Ciencias Médicas de la Pontificia Universidad Catolica de Chile, con especialización en Biologia Molecular en la Universidad de Mississippi y Universidad de Verona.

Bioquimico MS, Pontificia Universidad Catolica de Chile.

Doctor en Ciencias Médicas, Pontificia Universidad Catolica de Chile.

  • Enfermedades cardiovasculares y alteraciones de la hemostasia.
  • Hipertension endocrina
  • Hiperaldosteronismo
  • Sindrome de exceso aparente de mineralocorticoides
  • Genética y epigenética de la Hipertensión endocrina
  • Rol de las vesiculas extracelulares pequeñas en patologia endocrina
  • Desarrollo de nuevos fármacos para el tratamiento de la hipertensión y el síndrome metabólico.

  • Carvajal CA, Tapia-Castillo A, Pérez JA, Fardella CE. Primary Aldosteronism, Aldosterone, and Extracellular Vesicles. Endocrinology. 2022 Jan 1;163(1):bqab240. doi: 10.1210/endocr/bqab240. PMID: 34918071.

  • Pastén V, Tapia-Castillo A, Fardella CE, Leiva A, Carvajal CA. Aldosterone and renin concentrations were abnormally elevated in a cohort of normotensive pregnant women. Endocrine. 2022 Mar;75(3):899-906. doi: 10.1007/s12020-021-02938-0. Epub 2021 Nov 26. PMID: 34826118.

  • Carvajal CA, Tapia-Castillo A, Pérez JA, Fardella CE. Serum Alpha-1-Acid Glycoprotein-1 and Urinary Extracellular Vesicle miR-21-5p as Potential Biomarkers of Primary Aldosteronism. Front Immunol. 2021 Nov 5;12:768734. doi: 10.3389/fimmu.2021.768734. PMID: 34804057; PMCID: PMC8603108.

  • FONDECYT Regular 1212006, Study of exosomal proteins and miRNAs associated to the inflammatory response by high mineralocorticoid activity and its role as novel biomarkers in primary aldosteronism. Investigador responsable: Cristián Carvajal (Abril 2021 – Marzo 2025).

  • Centro Traslacional de Endocrinologia UC. Director Ciencias Básicas. Investigador principal (2019-2023).
    Conoce más.

  1. Carvajal CA, Tapia-Castillo A, Vecchiola A, Baudrand R, Fardella CE. Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome. J Clin Endocrinol Metab. 2019 Dec 31. pii: dgz315. doi: 10.1210/clinem/dgz315. [Epub ahead of print] PubMed PMID: 31909799. Autor correspondiente.
  2. Martinez-Aguayo AG, Campino C, Carvajal C, Arancibia M, Ossa JT, Sifaqui S, Fardella CE, Baudrand R et al. Urinary sodium-to-potassium ratio and plasma renin and aldosterone concentrations in normotensive children: implications for the interpretation of results. J Hypertens. 2019 Dec 4. doi: 10.1097/HJH.0000000000002324. [Epub ahead of print] PubMed PMID: 31790052.
  3. Tapia-Castillo A, Vecchiola A, Fardella CE, Salomón C, Carvajal CA et al. Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess. J Transl Med. 2019 Nov 27;17(1):392. doi: 10.1186/s12967-019-02143-8. PubMed PMID: 31775784; PubMed Central PMCID: PMC6880399. Autor correspondiente.
  4. Arteaga E, Valenzuela F, Lagos CF, Lagos M, Martinez A, Baudrand R, Carvajal C, Fardella CE. Detection of a novel severe mutation affecting the CYP21A2 gene in a Chilean male with salt wasting congenital adrenal hyperplasia. Endocrine. 2020 Jan;67(1):258-263. doi: 10.1007/s12020-019-02097-3. Epub 2019 Sep 30. PubMed PMID: 31571129.
  5. Vecchiola A, Fuentes CA, Barros ER, Martínez-Aguayo A, García H, Allende F, Solari S, Olmos R, Carvajal C, Tapia-Castillo A, Campino C, Kalergis AM, Baudrand R, Fardella CE. The Aldosterone/Renin Ratio Predicts Cardiometabolic Disorders in Subjects Without Classic Primary Aldosteronism. Am J Hypertens. 2019 Apr 22;32(5):468-475. doi: 10.1093/ajh/hpz023. PubMed PMID: 30753255.
  6. Tapia-Castillo A, Baudrand R, Vaidya A, Carvajal CA, Fardella CE et al. Clinical, Biochemical, and Genetic Characteristics of «Nonclassic» Apparent Mineralocorticoid Excess Syndrome. J Clin Endocrinol Metab. 2019 Feb 1;104(2):595-603. doi: 10.1210/jc.2018-01197. Erratum in: J Clin Endocrinol Metab. 2019 May 1;104(5):1679. PubMed PMID: 30239803. Autor correspondiente.
  7. Campino C, Baudrand R, Valdivia CA, Carvajal C, Vecchiola A, Tapia-Castillo A, Fardella CE et al. Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation. Am J Hypertens. 2018 Sep 11;31(10):1127-1132. doi: 10.1093/ajh/hpy097. Erratum in: Am J Hypertens. 2018 Nov 13;31(12):1334. PubMed PMID: 29917063.
  8. Carvajal CA, Tapia-Castillo A, Baudrand R, Fardella CE et al. Serum Cortisol and Cortisone as Potential Biomarkers of Partial 11β-Hydroxysteroid Dehydrogenase Type 2 Deficiency. Am J Hypertens. 2018  Jul 16;31(8):910-918. doi: 10.1093/ajh/hpy051. PubMed PMID: 29617893. Autor correspondiente
  9. Barros ER, Carvajal CA. Urinary Exosomes and Their Cargo: Potential Biomarkers for Mineralocorticoid Arterial Hypertension? Front Endocrinol (Lausanne). 2017 Sep 8;8:230. doi: 10.3389/fendo.2017.00230. eCollection 2017. Review. PubMed PMID: 28951728; PubMed Central PMCID: PMC5599782. Autor correspondiente
  • Tapia-Castillo A, Carvajal CA, Allende F, Campino C, Fardella CE. Hypertensive Patients That Respond to Aldosterone Antagonists May Have a Nonclassical 11β-HSD2 Deficiency. Am J Hypertens. 2017 Aug 1;30(8):e6. doi: 10.1093/ajh/hpx065. PubMed PMID: 28430837. Autor equal contribution.

Revisar todas las publicaciones aquí.

Revisar todas las publicaciones aquí. 

 

  1. Cristian Carvajal & Jose Luis Santos. Genetica y Epigenetica. Editor Eugenio Arteaga.  In Book “Manual de Endocrinologia”. 2017. ISBN: 978-956-220-402-6. Editorial: MEDITERRANEO. Edicion/Año: 2018. https://mediterraneo.cl/medicina/8-endocrinologia-clinica-2ed.html
  2. Cristian Carvajal & Carlos Fardella. Hiperaldosteronismo Primario. Editor Eugenio Arteaga.  In Book “Manual de Endocrinologia”. 2017. ISBN: 978-956-220-402-6. Editorial: MEDITERRANEO. Edicion/Año: 2018. https://mediterraneo.cl/medicina/8-endocrinologia-clinica-2ed.html
  3. Simonetta Friso*, Cristian Carvajal* et al. CH.7: “EPIGENETICS AND ARTERIAL HYPERTENSION: EVIDENCES AND PERSPECTIVES”. 2017. (*equal contribution); Edited by Jeffrey Lawrence. Elsevier Eds. https://www.elsevier.com/books/translating-epigenetics-to-the-clinic/laurence/978-0-12-800802-7
  4. Carvajal CA, Mellado, C. “Aspectos geneticos de la endocrinologia ginecologica”. Libro ENDOCRINOLOGÍA GINECOLÓGICA. Editor Eugenio Arteaga. ISBN: 978-956-220-381-4. EDITORIAL: Mediterráneo. EDICIÓN/AÑO: 2016. https://mediterraneo.cl/medicina/57-endocrinologia-ginecologica.html
  • Outstanding late-breaking abstract. ENDO Meeting  2019.  Granted by The Endocrine Society. Estados Unidos, 2019.
  • Grant 2019 SOCHED. SOCIEDAD CHILENA DE ENDOCRINOLOGIA Y METABOLISMO. Chile, 2019
  • Minisabbatical Programe UC in University of Queensland, Brisbane, Australia. 2017. Granted by Pontificia Universidad Catolica de Chile
  • Collaborative Grant. Chile, 2017. Universidad del Desarrollo & University of Queensland.
  • Best work of the 27th SOCHED meeting. Chile. Awarded by Sociedad Chilena de Endocrinologia y Diabetes.
  • Travel Award to 26th Scientific Meeting of the ISH. Awarded by International society of Hypertension.
  • Excellence in Doctoral Thesis award. Chile, 2014. Awarded by Pontificia Universidad Católica de Chile
  • Research Grant SOCHED. Chile, 2012. Sociedad Chilena de Endocrinologia y Diabetes.
  • Presidential Abstract Award. 95th The Endocrine Society 2013. Estados Unidos, 2013