Departamento de Gastroenterología
Facultad de Medicina 
Pontificia Universidad
Católica de Chile
Marcoleta #367, Santiago
CHILE
Teléfonos:
(56-2)2639 7780
(56-2)2354 3820

Inicio Equipo Soza (English)
Equipo
Alejandro Soza (English)
Gastroenterology
Soza (English)

Cargo:

  Hepatology Fellowship 

Liver Diseases Branch, NIDDK 
National Institutes of Health, NIH 
USA (July 2001 - July 2003)

Gastroenterology Residency
Department of Gastroenterology 
Catholic University of Chile 
School of Medicine (June 1998 - May 2000)

Liver Unit, Clinic Hospital 
Barcelona, Spain, (September-November 1997)

Internal Medicine Residency 
Catholic University of Chile 
School of Medicine (May 1995 - April 1998)

Contacto:

Department of Gastroenterology
Pontificia Universidad Católica de Chile
Marcoleta 367
Santiago 8330024
Chile
Phone: 56-2-3543820
Fax: 56-2-6397780
E-mail: asoza@med.puc.cl
Web page: www.hepatitis.cl
twitter.com/AlejandroSoza

Formación Pregrado :

M. D.
Catholic University of Chile
School of Medicine (1995)

Actividades Docentes Asistenciales :

Gastroenterology Residency Program Director
(2008-until now)

Associate Professor
Department of Gastroenterology
Catholic University of Chile
(2009-until now)

Assistant Professor
Department of Gastroenterology
Catholic University of Chile
(2005-2009)

Instructor
Department of Gastroenterology
Catholic University of Chile
(2000-2005)


Research grants:

1. “Hepatitis C virus exploits the hepatic lipid pathways: Role of NPC1L1 in HCV infection”. Grant from FONDECYT (National Fund of Science and Technology, Chile). N° 1130357. 2013-2016. Principal Investigator.

2. “Role of extrahepatic replication of hepatitis C virus in the prediction of response to antiviral therapy”. Grant from FONDECYT (National Fund of Science and Technology, Chile). N° 1080323. 2008-2011. Principal Investigator.

3. “Evaluation of Results of the Pilot Program of Hepatitis C Treatment”. Grant from FONIS (National Fund for Health Investigation). 2007-2009. Principal Investigator.

4. “Capture and enrichment of emerging pathogens for multiple and ultra-sensitive diagnostic (USDEP)” (FP6-2005-Lifesciheaalth-7). 2006-2008. Local co- investigator.

5. “Recherches sur le plans diagnostic et physiopathologique chez les Virus Emergents” (JEAI-IRD). 2006-2008. Local co-investigator.

6. “Role of extrahepatic viral replication on the natural history and clinical manifestations of chronic hepatitis C”. Grant from FONDECYT (National Fund of Science and Technology, Chile). N° 1050782. 2005-2007. Principal Investigator.

7. Grant of Center of Medical Research, Catholic University, for the study of“Cytokines in Non-Alcoholic Steato-Hepatitis”, 1999.

8. Grant of Center of Medical Research, Catholic University, for the study of “Hepatitis G Virus Prevalence in Chilean Hemophiliacs”, 1998.

Libros :

1. Soza A. “Direct acting antiviral agents”. In: Viral hepatitis. Epidemiological,

clinical and basic concepts. Editor: Nahum Mendez-Sanchez. (In press).

2. Soza A, Lopez-Lastra M. “Infección por hepatitis C”. En: Virología Clínica. Editores Araneda LF, Ferres M, Spencer E. Editorial Mediterráneo. 2010. Santiago, Chile.

3. Soza A, Martínez J, Pérez-Ayuso RM, Arrese M. “Insuficiencia hepática aguda”. Páginas 534-546. En: Medicina Intensiva. Editores: Bugedo G, Castillo L, Dougnac A. Editorial Mediterráneo. 2005. Santiago, Chile.

4. Soza A, Abarzúa F. "Hepatitis virales y embarazo". En: Alto Riesgo Obstétrico. Enrique Oyarzún, editor. Santiago, Publicaciones Universitarias PUC.

Otras Publicaciones :

Publications:

1.“IL28B Polymorphisms Among Latin American HCV Patients”. Soza A, Lopez- Lastra M. Curr Hepatitis Rep. 2013;12:276–279.

2.“An update on the management of hepatitis C: guidelines for protease inhibitor- based triple therapy from the Latin American Association for the Study of the Liver”. Chávez-Tapia NC, Ridruejo E, Alves de Mattos A, Bessone F, Druich J, Sánchez- Avila JF, Cheinquer H, Zapata R, Uribe M, Bosques-Padilla F, Gadano A, Soza A, Dávalos-Moscol M, Marroni C, Muñoz-Espinoza L, Castro-Narro G, Paraná R, Méndez- Sánchez N. Ann Hepatol. 2013;12(2):S3-S35.

3.Angulo J, Pino K, Pavez C, Biel F, Labbé P, Miquel JF, Soza A, López-Lastra M. “Genetic variations in host IL28B links to the detection of peripheral blood mononuclear cells-associated hepatitis C virus RNA in chronically infected patients”. J Viral Hepat. 2013 Apr;20(4):263-72.

4.Gabrielli M, Moisan F, Vidal M, Duarte I, Jiménez M, Izquierdo G, Domínguez P, Méndez J, Soza A, Benitez C, Pérez R, Arrese M, Guerra J, Jarufe N, Martínez J. “Steatotic livers. Can we use them in OLTX? Outcome data from a prospective baseline liver biopsy study”. Ann Hepatol. 2012;11(6):891-8.

5.Soza A. "Hepatitis C RNA clearance after treatment with ezetimibe". Liver Int. 2012;32(8):1323-4.

6.Manns MP, Gane E, Rodriguez-Torres M, Stoehr A, Yeh CT, Marcellin P, Wiedmann RT, Hwang PM, Caro L, Barnard RJ, Lee AW; for the MK-7009 Protocol 007 Study Group. "Vaniprevir with peginterferon alfa-2a and ribavirin in treatment-naive patients with chronic hepatitis C - a randomized phase 2 study". Hepatology. 2012 56(3):884- 893.7.Benítez C, Arancibia JP, Arrese M, Soza A, Domínguez P, Jarufe N, Martínez J, Pérez- Ayuso RM. “Operational tolerance after liver transplantation, more common than we think: A case report”. Ann Hepatol. 2011;10(3):361-4.

8.Salech F, Valderrama S, Nervi B, Rodríguez JC, Oksenberg D, Koch A, Smok G, Duarte I, Pérez-Ayuso RM, Jarufe N, Martínez J, Soza A, Arrese M, Riquelme A. “Thalidomide for the treatment of metastatic hepatic epithelioid hemangioendothelioma: a case report with a long term follow-up”. Ann Hepatol. 2011; 3;10(1):99-102.

9.Arrese M, Riquelme A, Soza A. “Insulin resistance, hepatic steatosis and hepatitis C: a complex relationship with relevant clinical implications”. Ann Hepatol. 2010;9 Suppl:112-118.

10.Soza A, Riquelme A, Arrese M. “Routes of transmission of hepatitis C virus”. Ann Hepatol. 2010;9 Suppl:30-33.

11.Latin American Association for the Study of the Liver. “Latin American Association for the Study of the Liver Practice Guidelines. Diagnosis, management, and treatment of hepatitis C”. Ann Hepatol. 2010;9 Suppl:8-26.

12.Barrera F, Soza A. “Shortened therapy for genotype 1 hepatitis C virus. The final answer?” Ann Hepatol. 2010;9(1):112-3.

13.Rotman Y, Borg BB, Soza A, Feld JJ, Modi AA, Loomba R, Lutchman G, Rivera E, Doo E, Ghany MG, Heller T, Neumann AU, Liang TJ, Hoofnagle JH. “Clinical trial: low- and standard-dose peginterferon alfa-2a for chronic hepatitis C, genotype 2 or 3 - efficacy, tolerability, viral kinetics and cytokine response”. Aliment Pharmacol Ther. 2010; 31(9):1018-27.

14.Caneo C, González M, Repetto P, Soza A. “Trastornos psiquiátricos y cognitivos de la hepatitis C y su tratamiento con interferón”. Rev Med Chile 2010;138:1431-40.

15.Gabrielli M, Vivanco M, Hepp J, Martínez J, Pérez R, Guerra J, Arrese M, Figueroa E, Soza A, Yáñes R, Humeres R, Rios H, Palacios JM, Zapata R, Sanhueza E, Contreras J, Rencoret G, Rossi R, Jarufe N. “Liver transplantation results for hepatocellular carcinoma in Chile”. Transplant Proc. 2010;42(1):299-301.

16.Vivanco M, Gabrielli M, Jarufe N, Humeres R, Rios H, Palacios JM, Zapata R, Sanhueza E, Contreras J, Rencore G, Rossi R, Martínez J, Pérez R, Guerra J, Arrese M, Figueroa E, Soza A, Yáñes R, Hepp J. “Bridge therapy in hepatocellular carcinoma before liver transplantation: the experience of two Chilean centers”. Transplant Proc. 2010;42(1):296-8.

17. Soza A, Palma R. “Requisitos para la acreditación de centros y programas universitarios en gastroenterología”. Gastr Latinoam 2010;21(4):502-9.

18.Nazal L, Barría P, Acuña D, Rivas A, Vera N, Valiente D, Jiménez J, Cudworth M, Barra L, Contreras A, Salas I, Alvarez M, Soza A, Riquelme A. “Alteración de pruebas hepáticas en pacientes chilenos con enfermedades hepáticas agudas y crónicas”. Gastr Latinoam 2010:21(4):459-67.

19.Riquelme A, de la Fuente P, Méndez B, Salech F, Valderrama S, Méndez JI, Oporto J, Miquel JF, Defilippi C, Soza A, Sirham M, Sáenz R. “Identificación de las competencias del gastroenterólogo chileno: Técnica Delphi modificada”. Gastr Latinoam 2010;21(4):437-53.

20.Rojas C, Méndez L, Arab JP, Barrera F, Soza A, Nervi F, Duarte I, Pulgar MA, Paredes N, Molgó M, Amador R, Cariqueo M, Riquelme A. “Síndrome de DRESS. Eritema cutáneo, fiebre y hepatitis asociado a lamotrigina. Reporte de dos casos y revisión de la literatura”. Gastr Latinoam 2010;21(3):357-62.

21.Soza A, San Martín AM, Jofré L, Noriega LM, Hunter B, Muñoz G, Becerra M, Martínez MC, Soto K, Rivera M, Tohá D. “Guía clínica de manejo de la infección por virus de la Hepatitis C”. Gastr Latinoam 2010;21(3):379-409.

22. Arab JP, Pavez C, Soza A, Arrese MA, Riquelme A. “Hepatitis colestásica por Mycoplasma pneumonia sin compromiso pulmonar. Caso clínico y revisión de la literature”. Gastr Latinoam 2010;21(2):85-8.

23. Soza A, Larraín S. “Hepatotoxicidad por verapamil. Reporte de un caso”. Gastr Latinoam. 2010;21(1):27-9.

24.Castro F, Riquelme A, Accatino L, Huete A, Besa C, Velásquez C, Soza A. “Fasciolasis hepática: Enfermedad con múltiples presentaciones”. Gastr Latinoam. 2009;20(4):308- 13.

25.Barrera F, Riquelme A, Soza A, Contreras A, Barrios G, Padilla O, Viviani P, Pérez- Ayuso RM. “Platelet count/spleen diameter ratio for non-invasive prediction of high risk esophageal varices in cirrhotic patients”. Ann Hepatol. 2009;8(4):325-30.

26.Vera-Otarola J, Barría MI, León U, Carvallo P, Soza A, Marcelo López-Lastra M. “Is single-strand conformation polymorphism analysis of the full 5’untranslated region an adequate approach to study hepatitis C virus quasispecies distribution?” Journal of Virology. 2009;83(17):9018-21.

27.Vera-Otarola J, Barrıa MI, Leon U, Marsac D, Carvallo P, Soza A, Lopez-Lastra M. “Hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naïve chronically infected patients”. J Viral Hepat. 2009;16(9):633-43.

28.Barrıa MI, Gonzalez A, Vera-Otarola J, Leon U, Vollrath V, Marsac D, Monasterio O, Perez-Acle T, Soza A, Lopez-Lastra M. “Analysis of natural variants of the hepatitis C virus internal ribosome entry site reveals that primary sequence

plays a key role on cap-independent translation”. Nucleic Acids Research. 2009;37(3):957-71.

29.Riquelme A, Arrese M, Soza A, Morales A, Baudrand R, Pérez-Ayuso RM, González R, Alvarez M, Hernández V, García-Zattera MJ, Otarola F, Medina B, Rigotti A, Miquel JF, Marshall G, Nervi F. “Non-alcoholic fatty liver disease and its association with obesity, insulin resistance and increased serum levels of C- reactive protein in Hispanics”. Liver Int. 2009;29(1):82-8.

30.Barría MI, Vera-Otarola J, León U, Vollrath V, Marsac D, Riquelme A, López-Lastra M, Soza A. “Influence of extrahepatic viral infection on the natural history of hepatitis C”. Ann Hepatol. 2008;7:136-43.

31.Soza A. “Hepatitis autoinmune”. Gastr Latinoam. 2007;18:193-7.

32.Riquelme A, Soza A, Pedreros C, Bustamant A, Valenzuela F, Otarola F, Abbott E, Arellano M, Medina B, Pattillo A, Greig D, Arrese M, Rollan A. “Optimal length of triple therapy for H pylori eradication in a population with high prevalence of infection in Chile”. World J Gastroenterol. 2007;13:2967-72.

33.Cerda C, Perez-Ayuso RM, Riquelme A, Soza A, Villaseca P, Sir-Petermann T, Espinoza M, Pizarro M, Solis N, Miquel JF, Arrese M. “Nonalcoholic fatty liver disease in women with polycystic ovary syndrome”. J Hepatol. 2007;47:412-7.

34.Riquelme A, Calvo M, Salech F, Valderrama S, Pattillo A, Arellano M, Arrese M, Soza A, Viviani P, Letelier, LM. “Value of adenosine deaminase (ADA) in ascitic fluid for the diagnosis of tuberculous peritonitis: A meta-analysis”. J Clin Gastr. 2006;40:705–10.

35.Soza A, López-Lastra M. “Hepatitis C en Chile: Magnitud del problema”. Rev Med Chil. 2006;134:777-88.

36. Jarufe N, Soza A, Perez-Ayuso RM, Poblete JA, Gonzalez R, Guajardo M, Hernandez V, Riquelme A, Arrese M, Martınez J. "Successful liver transplantation and delivery in a woman with fulminant hepatic failure occurring during the second trimester of pregnancy". Liver International. 2006;26:494–7.

37.Vial P, Riquelme A, Pizarro M, Solís M, Madariaga JM, Aguayo G, Duarte I, Soza A, Accatino L, Arrese M. “Pentoxifylline does not prevent neither liver damage nor early profibrogenic events in a rat model of non-alcoholic steatohepatitis”. Ann Hepatol. 2006;5:25-29.

38.Quinteros JI, Barrera F, Valderrama S, Salech F, Veas E, Espinoza M, Salas I, Soza A, Zárate V, Valdivia G, Bastías G, Riquelme A. “Evaluación crítica de artículo económico: Análisis Costo-utilidad de estrategias de profilaxis secundaria en hemorragia variceal”. Gastr Latinoam. 2006;17:86-98.

39.Boza C, Riquelme A, Ibanez L, Duarte I, Norero E, Viviani P, Soza A, Fernandez JI, Raddatz A, Guzman S, Arrese M. “Predictors of Nonalcoholic Steatohepatitis (NASH) in Obese Patients Undergoing Gastric Bypass”. Obes Surg. 2005;15(8):1148-53.

40.Soza A, Riquelme A, Gonzalez R, Alvarez M, Perez-Ayuso RM, Glasinovic JC, Arrese M. “Increased orocecal transit time in patients with nonalcoholic fatty liver disease”. Dig Dis Sci. 2005;50:1136-40.

41.Salech F, Valderrama S, Espinoza M, Salas I, Veas E, Barrera F, Quinteros JI, Soza A, Letelier LM, Riquelme A. “Evaluación de Test Diagnóstico. Utilidad de adenosin deaminasa (ADA) en el diagnóstico de peritonitis tuberculosa”. Gastr Latinoam. 2005;16:262-268.

42.Soza A, Heller T, Ghany M, G, Liang J, Germain J, Hsu HH, Park Y, Hoofnagle JH. “Pilot study of interferon gamma for chronic hepatitis C”. J Hepatol. 2005;43:67- 71.

43.González R, Soza A, Hernández V, Pérez RM, Alvarez M, Morales A, Arrellano M, Riquelme A, Viviani P, Covarrubias C, Arrese M, Miquel JF, Nervi F. “Incidence and prevalence of hepatitis C virus infection in Chile”. Ann Hepatol. 2005;4:127- 30.

44.Barrera F, Valderrama S, Salech F, Veas E, Espinoza M, Salas I, Quinteros JI, Soza A, Letelier LM, Riquelme A. “Evaluación de meta-análisis: Utilidad de corticoides en el tratamiento de la hepatitis alcohólica grave”. Gastr Latinoam. 2005;16:58-68.

45.Soza A, Arrese M, González R, Alvarez M, Pérez RM, Cortés P, Patillo A, Riquelme A. “Clinical and epidemiological features of 147 Chilean patients with chronic hepatitis C”. Ann Hepatol. 2004;3:146-51.

46.Veas E, Barrera F, Salas I, Espinoza M, Quintero JI, Soza A, Letelier LM, Riquelme A. “Evaluación de estudios de tratamiento: Utilidad de pentoxifilina en el tratamiento de la hepatitis por alcohol grave”. Gastr Latinoam. 2004;15:208-218.

47.Castillo C, Benítez C, Baccigaluppi G, Soza A, Riquelme A. “Empiema bacteriano espontáneo en paciente cirrótico”. Gastr Latinoam. 2004;15:203-7.

48.Riquelme A, Soza A, Nazal L, Martínez G, Kolbach M, Patillo A, Arellano JM, Duarte I, Martínez J, Molgó M, Arrese M. “Histological resolution of steatohepatitis after iron depletion”. Dig Dis Sci. 2004;49:1012-5.

49.Soza A. “Hepatitis tóxica: Acetaminofeno y otras”. Gastr Latinoam. 2004;15:158- 162.

50.Promrat K, Lutchman G, Uwaifo GI, Freedman RJ, Soza A, Heller T, Doo E, Ghany M, Premkumar A, Park Y, Liang TJ, Yanovski JA, Kleiner DE, Hoofnagle JH. "A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis". Hepatology. 2004;39:188-96.

51. Soza A, Hoofnagle JH. "Mortality rate during interferon alfa-ribavirin combination therapy of chronic hepatitis C" (Letter). Hepatology. 2003;38:267.

52.Hoofnagle JH, Ghany MG, Kleiner DE, Doo E, Heller T, Promrat K, Ong J, Khokhar F, Soza A, Herion D, Park Y, Everhart JE, Liang TJ. "Maintenance therapy with ribavirin in patients with chronic hepatitis C who fail to respond to combination therapy with interferon alfa and ribavirin". Hepatology. 2003;38:66-74.

53. Promrat K, McDermott DH, Gonzalez CM, Kleiner DE, Koziol DE, Lessie M, Merrell M, Soza A, Heller T, Ghany M, Park Y, Alter HJ, Hoofnagle JH, Murphy PM, Liang TJ. "Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C". Gastroenterology. 2003;124:352-360.

54.Soza A, Lau DT, Khokhar MF, Conjeevaram H, Park Y, Hoofnagle JH. "Resolution of chronic hepatitis B-associated autoimmune neutropenia with alpha interferon therapy". J Pediatr Gastroenterol Nutr. 2003;36:141-3.

55. Soza A, Everhart J, Ghany M, Doo E, Heller T, Promrat K, Park Y, Liang J, Hoofnagle JH. "Neutropenia associated with alpha interferon therapy of chronic hepatitis C". Hepatology. 2002;36:1273-1279.

56. Soza A, Riquelme F, Álvarez M, Duarte I, Arrese M. "Hepatotoxicity by amoxicillin-clavulanic acid: Case report and review". Rev Med Chil. 127(12):1487-1491,1999.

57.Martínez A, Muñoz V, Lisboa C, Jalil J, Godoy I, Moreno R, Ferretti R, Casanegra P, Saldías F, Guarda E, Corbalán R, Arroyo C, Soza A, Morales RA, Pozo I, Arancibia C. "Non-invasive intermittent mechanical ventilation: usefulness in treatment of chronic severe heart failure". Rev Med Chil. 1995;123:1467-75.

58.Enríquez R, Escalona J, Oyarzún E, Chuaqui R, Soza A, Contreras G. "Complicated placental chorioangioma: infrequent cause of premature labor". Rev Chil Obstet Ginecol. 1994;59:390-2.

59.Martínez A, Fajuri A, Corbalán R, Marchant E, Dussaillant E, Castellón J, Sanhueza G, Zepeda S, Arroyo C, Soza A. "Incidence and features of cardiogenic shock in AMI: a comparison of the pre and post thrombolytic periods". Rev Chil Card. 1993;12:116-8.

Sociedades, comités editoriales, premios :

Academic Honors and Recognition

“Young Investigator Award” from de School of Medicine, Pontificia Universidad Católica de Chile. 2008.

Best research presentation award. Sociedad Chilena de Infectología. Pucón, 2007.

“Dr. Jaime Chesta Award” from the Chilean Society of Gastroenterology. This award is given to a young investigator with projection. 2003.

"President of the Republic" career award, from the Chilean Ministry of Planification (MIDEPLAN), for support of training abroad. 2001.

ECFMG certified. USMLE: Step 1 (basic sciences) Score 231 (92). Step 2 (clinical sciences) Score 234 (89). English test, 1998.

Scholarship from Catholic University of Chile School of Medicine (support of Gastroenterology Fellowship), 1998.

Scholarship from Catholic University of Chile School of Medicine (support of Internal Medicine Residency), 1995.

"Dr. Gabriel Letelier" Award (for the best graduate of the Internal Medicine Internship), 1995.

National best score in Biology and Mathematics Academic Tests (among all applicants to the Chilean University System), 1987.

  

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